(Blood-brain barrier, BBB)
Caqabadda maskaxda iyo dhiigga waa mid ka mid ah hababka is-difaaca muhiimka ah ee bini'aadamka.Waxay ka kooban tahay unugyada endothelial capillary maskaxda, unugyada glial, iyo choroid plexus, taas oo u oggolaanaysa kaliya noocyo gaar ah oo ka mid ah molecules ee dhiigga inay galaan neerfayaasha maskaxda iyo unugyada kale ee ku xeeran, waxayna ka hortagi karaan walxaha kala duwan ee waxyeellada leh inay galaan unugyada maskaxda.Maskaxdu, sida qayb muhiim ah oo ka mid ah jidhka bini'aadamka, ayaa maamusha hawlo badan oo muhiim ah.Caqabadda maskaxda iyo dhiigga waxay xannibi kartaa walxaha waxyeellada leh ee dhiigga waxayna ilaalin kartaa badbaadada unugyada maskaxda.
Cudurka Alzheimer, AD
Cudurka Alzheimers (AD) waa cudur neurodegenerative horusocod ah oo leh bilow qarsoodi ah.Dhaqdhaqaaqa kiliinikada, waallida dhamaystiran waxaa lagu gartaa xusuusta daciifka ah, aphasia, aphasia, luminta aqoonsiga, daciifnimada xirfadaha muuqaalka iyo goobta, hawlgabka fulinta, iyo shakhsiyadda iyo isbeddelada dabeecadda.Ilaa iyo hadda lama garanayo xanuunka etiology.Waallida degdega ah waxaa loola jeedaa shakhsiyaadka leh calaamadaha ka hor da'da 65;Shakhsiyaadka ku dhaca waallida ka dib da'da 65 waxaa loo tixraacaa waallida waayeelka.Dhacdada cudurka Alzheimers (AD) ayaa inta badan lala xiriiriyaa β-Amyloid borotiinka (A β) Accumulation iyo borotiinka Tau ayaa isku xiran, cilmi baaris badan ayaa si tartiib tartiib ah u taxaysa neuroinflammation mid ka mid ah arrimaha gacan ka geysta dhacdada AD.
Xigasho: Waa maxay cudurka Alzheimers?Bal u fiirso aqoontan.Daily People Online.2023-09-20
Ogow in ay jirto nooc bakteeriya ah oo geli karta xannibaadda dhiigga iyo maskaxda
Dhawaan, cilmi-baarayaal ka socda Baylor College of Medicine ee Maraykanka ayaa daabacay warqad cilmi-baaris ah oo cinwaankeedu yahay: Toll like reseptor 4 iyo CD11b ayaa lagu muujiyay isku-dubarid microglia ee Candida albicans cerebral mycosis ee joornaalka hoose ee Warbixinta Unugyada.
Waxaan helnay fungus la yiraahdo Candida albicans oo maskaxda ka geli kara qulqulka dhiigga.Maahmaah caanka ah ayaa tidhaahda, "Lugta curyaanka oo la laado waxay keeni kartaa cudurka Alzheimers sida isbeddello oo kale."Daraasaddan, waxaan sii daaha ka qaadnay hababka molecular ee ay Candida albicans ka jabiso xannibaadda dhiigga-maskaxda oo ay gasho maskaxda, taasoo keenta cudurka Alzheimers sida isbeddellada.
Sidee Candida albicans u galaan maskaxda?"Waxaan ogaanay in Candida albicans ay soo saarto enzim loo yaqaan aspartate protease (Saps), kaas oo carqaladeeya xannibaadda dhiigga-maskaxda, taas oo u oggolaanaysa fungi inay galaan maskaxda oo ay waxyeello u geystaan," ayuu yiri Dr. Yifan Wu, oo ah saynisyahanka caafimaadka carruurta ee postdoctoral oo ka shaqeeya Corry. Shaybaadhka.
Candida albicans
Candida albicans (magaca sayniska: Candida albicans) waa khamiir keeni kara caabuqyo fursad ah.Waxaa caadi ahaan laga helaa bulshada bakteeriyada ee habka dheefshiidka iyo kaadi mareenka aadanaha.Qiyaastii 40% ilaa 60% dadka qaangaarka ah ee caafimaadka qaba ayaa Candida albicans ku leh marinnada afka iyo dheefshiidka.Candida albicans caadi ahaan waxay la nool yihiin jidhka bini'aadamka, laakiin way badin karaan inta lagu jiro yaraanta difaaca waxayna sababi karaan candidiasis.Waa bakteeriyada ugu badan ee bakteeriyada pathogenic ee Candida genus
Sida laga soo xigtay daraasad lagu daabacay Cell Reports, fungi oo aynaan inta badan fiiro gaar ah siin waxay sidoo kale noqon kartaa mid ka mid ah dembiilayaasha cudurka Alzheimers.Cilmi-baarayaasha Baylor School of Medicine iyo machadyada iskaashanaya waxay ku ogaadeen moodooyinka xayawaanka sida Candida albicans u gasho maskaxda iyo sida ay u shaqeyso laba hab oo madax-bannaan oo unugyada maskaxda ah kuwaas oo kor u qaada nadiifinteeda (taas oo muhiim u ah fahamka horumarinta cudurka Alzheimers), oo ay soo saareen. β Amyloid protein (A β）) Peptides (goobyada borotiinka sunta ah ee borotiinka amyloid) ayaa loo arkaa inay yihiin xudunta horumarka cudurka Alzheimers.
Dr. David Corry ayaa yiri.David Corry waa Guddoomiyaha Cilmi-nafsiga ee Fulbright Foundation iyo borofisar ku takhasusay cudurrada, immunology, iyo daawada ee Jaamacadda Baylor.Waxa kale oo uu xubin ka yahay Xarunta Kansarka ee Baylor L. Duncan.2019, waxaan ogaanay in Candida albicans ay runtii gashay maskaxda oo ay soo saarto isbeddello la mid ah cudurka Alzheimers.Caabuqa ay keento Candida albicans ayaa badanaa la socda
A β Sababta soo saarista amyloid sida peptides oo kale ah waa in Sap ay hydrolyzize karto borotiinnada amyloid precursor (APPs).
Si kastaba ha noqotee, peptides-yadani waxay sidoo kale soo jiitaan dareenka unugyada difaaca maskaxda - microglia, taas oo muhiim u ah nadiifinta soo socota ee Candida albicans maskaxda lafteeda.Intaa waxaa dheer, sunta Candidalysin ee ay soo saartay Candida albicans waxay dhaqaajisaa microglia iyada oo loo marayo waddo kale.Haddii dariiqan la carqaladeeyo, fangaska maskaxda lama tirtiri karo.
Cilmi-baarayaashu waxay tilmaameen in shaqadani ay noqon karto hal-xidhaale muhiim ah oo lagu fahmo dhacdada cudurka Alzheimers.Daraasado hore ayaa soo jeediyay in borotiinka maskaxda ku jira ay ku lug leeyihiin burburinta apps waxayna gacan ka geystaan A β Isku-ururinta ayaa dhigay aasaaska.Oo hadda waxaa la xaqiijin karaa in borotiinkan ka baxsan fangaska uu sidoo kale keeni karo A β Peptide sida wax soo saarka.
Cilmi-baadhayaashu waxay tilmaameen in qiimayn dheeraad ah oo lagu sameeyo doorka Candida albicans ee horumarinta cudurka Alzheimers loo baahan yahay mustaqbalka, taas oo sidoo kale u horseedi karta xeelado daaweyn cusub oo AD ah.
Qalabka tixraaca:
[1] Yifan Wu et al, Toll sida qaataha 4 iyo CD11b ayaa lagu muujiyey isku-dubbaridka microglia ee Candida albicans cerebral mycosis, Warbixinta Unugyada (2023) DOI: 10.1016/j.celrep.2023.113240
[2] Alaabooyinka caabuqa maskaxda ku shaqeeya ee cudurka Alzheimers sida isbeddellada, ayaa leh daraasad cusub oo laga helay Oktoobar 17, 2023 https://medicalxpress.com/news/2023-10-brain-fungal-infection-alzheimer-disease-like.html
Waqtiga boostada: Dec-22-2023